Elevated serotonin transporter binding in depressed patients with Parkinson's disease: A preliminary PET study with [11C]DASB
Identifieur interne : 002329 ( Main/Exploration ); précédent : 002328; suivant : 002330Elevated serotonin transporter binding in depressed patients with Parkinson's disease: A preliminary PET study with [11C]DASB
Auteurs : Isabelle Boileau [Canada] ; Jerry J. Warsh [Canada] ; Mark Guttman [Canada] ; Jean A. Saint-Cyr [Canada] ; Tina Mccluskey [Canada] ; Pablo Rusjan [Canada] ; Sylvain Houle [Canada] ; Alan A. Wilson [Canada] ; Jeffrey H. Meyer [Canada] ; Stephen J. Kish [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-09-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Aniline Compounds, Case-Control Studies, Depression, Depression (diagnostic imaging), Depression (etiology), Depression (pathology), Emission tomography, Female, Human, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (diagnostic imaging), Parkinson disease, Parkinson's disease, Positron emission tomography, Positron-Emission Tomography (methods), Prefrontal Cortex (diagnostic imaging), Protein Binding (drug effects), Psychiatric Status Rating Scales, Serotonin Plasma Membrane Transport Proteins (metabolism), Serotonin transporter, Statistics, Nonparametric, Sulfides, [11C]DASB, depression, positron emission tomography, serotonin transporter.
- MESH :
- chemical , metabolism : Serotonin Plasma Membrane Transport Proteins.
- chemical : Aniline Compounds, Sulfides.
- complications : Parkinson Disease.
- diagnostic imaging : Depression, Parkinson Disease, Prefrontal Cortex.
- drug effects : Protein Binding.
- etiology : Depression.
- methods : Positron-Emission Tomography.
- pathology : Depression.
- Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Statistics, Nonparametric.
Abstract
This study investigated whether abnormalities in serotonin transporter binding occur in Parkinson's disease (PD) patients with concurrent depression. We estimated serotonin transporter levels in seven clinically depressed early‐stage PD patients and in seven healthy matched‐control subjects during a single positron emission tomography (PET) scan with the serotonin transporter radioligand, [11C]DASB. Depressed PD patients displayed a wide‐spread increase (8–68%) in [11C]DASB specific binding outside of the striatum, which was significant in dorsolateral (37%) and prefrontal (68%) cortices. Elevated [11C]DASB binding was positively correlated with depressive symptoms but not with disease severity or duration. Compatible with recent PET/[11C]DASB findings in major depression, the present preliminary data suggest that increased [11C]DASB binding, possibly reflecting greater serotonin transporter density (up‐regulation), might be a pathological feature of depression in Parkinson's disease—and possibly a characteristic of depressive illness in general. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22212
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-09-15">2008-09-15</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1776">1776</biblScope><biblScope unit="page" to="1780">1780</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3E4E806CE8F04AC111F551310221FB49E5E50A48</idno><idno type="DOI">10.1002/mds.22212</idno><idno type="ArticleID">MDS22212</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aniline Compounds</term><term>Case-Control Studies</term><term>Depression</term><term>Depression (diagnostic imaging)</term><term>Depression (etiology)</term><term>Depression (pathology)</term><term>Emission tomography</term><term>Female</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Positron emission tomography</term><term>Positron-Emission Tomography (methods)</term><term>Prefrontal Cortex (diagnostic imaging)</term><term>Protein Binding (drug effects)</term><term>Psychiatric Status Rating Scales</term><term>Serotonin Plasma Membrane Transport Proteins (metabolism)</term><term>Serotonin transporter</term><term>Statistics, Nonparametric</term><term>Sulfides</term><term>[11C]DASB</term><term>depression</term><term>positron emission tomography</term><term>serotonin transporter</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Aniline Compounds</term><term>Sulfides</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Depression</term><term>Parkinson Disease</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Protein Binding</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Psychiatric Status Rating Scales</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Etat dépressif</term><term>Homme</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Tomographie par émission de positons</term><term>Tomoscintigraphie</term><term>Transporteur sérotonine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study investigated whether abnormalities in serotonin transporter binding occur in Parkinson's disease (PD) patients with concurrent depression. We estimated serotonin transporter levels in seven clinically depressed early‐stage PD patients and in seven healthy matched‐control subjects during a single positron emission tomography (PET) scan with the serotonin transporter radioligand, [11C]DASB. Depressed PD patients displayed a wide‐spread increase (8–68%) in [11C]DASB specific binding outside of the striatum, which was significant in dorsolateral (37%) and prefrontal (68%) cortices. Elevated [11C]DASB binding was positively correlated with depressive symptoms but not with disease severity or duration. Compatible with recent PET/[11C]DASB findings in major depression, the present preliminary data suggest that increased [11C]DASB binding, possibly reflecting greater serotonin transporter density (up‐regulation), might be a pathological feature of depression in Parkinson's disease—and possibly a characteristic of depressive illness in general. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Boileau, Isabelle" sort="Boileau, Isabelle" uniqKey="Boileau I" first="Isabelle" last="Boileau">Isabelle Boileau</name></region><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name><name sortKey="Mccluskey, Tina" sort="Mccluskey, Tina" uniqKey="Mccluskey T" first="Tina" last="Mccluskey">Tina Mccluskey</name><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H." last="Meyer">Jeffrey H. Meyer</name><name sortKey="Rusjan, Pablo" sort="Rusjan, Pablo" uniqKey="Rusjan P" first="Pablo" last="Rusjan">Pablo Rusjan</name><name sortKey="Saint Yr, Jean A" sort="Saint Yr, Jean A" uniqKey="Saint Yr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name><name sortKey="Saint Yr, Jean A" sort="Saint Yr, Jean A" uniqKey="Saint Yr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name><name sortKey="Warsh, Jerry J" sort="Warsh, Jerry J" uniqKey="Warsh J" first="Jerry J." last="Warsh">Jerry J. Warsh</name><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. Wilson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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